Vascular Cognitive Impairment: Information from Animal Models on the Pathogenic Mechanisms of Cognitive Deficits
نویسندگان
چکیده
منابع مشابه
Mild cognitive impairment: animal models
Mild cognitive impairment (MCI) is an aspect of cognitive aging that is considered to be a transitional state between normal aging and the dementia into which it may convert. Appropriate animal models are necessary in order to understand the pathogenic mechanisms of MCI and develop drugs for its treatment. In this review, we identify the features that should characterize an animal model of MCI,...
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15 صفحه اولVascular cognitive impairment.
Dementia, a syndrome of declining higher cognitive functioning, found in approximately 10 per cent of adults 65 years and older, and 50 per cent of adults older than 90 years. Alzheimer’s disease (AD) accounts for 50 to 80 per cent of all dementing illnesses. Vascular dementia comprises 15 to 20 per cent of dementia and in some clinico-pathological series is the second commonest form of dementi...
متن کاملVascular Cognitive Impairment.
Cerebrovascular disease typically manifests with stroke, cognitive impairment, or both. Vascular cognitive impairment refers to all forms of cognitive disorder associated with cerebrovascular disease, regardless of the specific mechanisms involved. It encompasses the full range of cognitive deficits from mild cognitive impairment to dementia. In principle, any of the multiple causes of clinical...
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The relationship between frailty and cognitive impairment has been recognized for decades, but it was not until a few years ago that the interest in this relationship increased and is now being understood. Epidemiological evidence suggests that physical frailty may be linked to cognitive impairment since both conditions share pathophysiological mechanisms at the cellular and systemic levels. Ag...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2019
ISSN: 1422-0067
DOI: 10.3390/ijms20102405